Biscuit Pizza Casserole: The Ultimate Easy Weeknight Dinner

By Natalie Quinn

On January 23, 2026

A scoop of ground beef pizza casserole on a spatula, being lifted from a baking dish, showing the cheesy layers.

Cuisine

American, Italian-American

Prep time

15 minutes

Cooking time

25 minutes

Total time

40 minutes

Servings

8 servings

Get ready to transform your weeknight dinner routine with this incredibly delicious and easy Biscuit Pizza Casserole. This recipe combines the savory, cheesy goodness of a classic pizza with the comforting, hearty nature of a casserole, all made ridiculously simple with canned biscuits. It’s a guaranteed family favorite that delivers all the flavor you crave with minimal effort. Perfect for busy evenings, this dish is a true game-changer for anyone who loves pizza but needs a quick and satisfying meal.

Why You’ll Fall in Love With This Biscuit Pizza Casserole

If you’re looking for a recipe that’s both a crowd-pleaser and a time-saver, you’ve found it. Here’s why this casserole will become a staple in your home:

  • Incredibly Easy: Using refrigerated biscuit dough as the crust eliminates all the work of making pizza from scratch. It’s a simple, straightforward recipe that even beginner cooks can master.
  • Family-Friendly: Kids and adults alike go crazy for this dish. It has all the familiar, comforting flavors of pizza in a fun, easy-to-eat casserole form.
  • Perfectly Customizable: Just like a regular pizza, you can tailor this casserole to your family’s tastes. Add your favorite toppings, switch up the cheese, or try a different sauce to make it your own.
  • Great for Leftovers: This casserole reheats beautifully, making it a fantastic option for next-day lunches or another quick dinner.

Key Ingredients for Your Casserole

This recipe uses simple, easy-to-find ingredients that come together to create something truly special. Here’s what you’ll need:

  • Ground Beef: One pound of lean ground beef creates the savory, meaty base. You can also substitute ground turkey or Italian sausage.
  • Pizza Sauce: A jar of your favorite pizza sauce brings that classic, tangy tomato flavor.
  • *Canned Refrigerated Biscuits: The magic ingredient! One can of large refrigerated biscuits (like Pillsbury Grands!) creates the fluffy, golden-brown crust.

  • Pepperoni: Sliced pepperoni adds a classic, slightly spicy pizza kick.
  • Shredded Mozzarella Cheese: Two cups of gooey, melted mozzarella are essential for that perfect cheese pull. Freshly shredded melts best!
  • Italian Seasoning: A teaspoon of this dried herb blend enhances all the flavors.
  • Garlic Powder & Onion Powder: These add depth and a savory aroma to the meat mixture.

For a side dish that complements the richness of the casserole, consider this delicious bright and crunchy carrot salad.

Step-by-Step Instructions to Make Biscuit Pizza Casserole

Follow these simple steps to assemble and bake your casserole to cheesy perfection. It’s a foolproof process that leads to a delicious dinner every time.

  1. Preheat and Prep: First, preheat your oven to 375°F (190°C). Grease a 9×13 inch baking dish and set it aside.
  2. Cook the Meat: In a large skillet, cook the ground beef over medium-high heat until it’s no longer pink. Drain off any excess grease. Stir in the pizza sauce, Italian seasoning, garlic powder, and onion powder. Let it simmer for a few minutes.
  3. Prepare the Biscuits: While the meat simmers, open the can of biscuits and cut each one into quarters.
  4. Assemble the Casserole: Spread half of the biscuit pieces in an even layer in the bottom of your prepared baking dish. Top with half of the meat sauce, half of the pepperoni, and half of the mozzarella cheese. Repeat the layers with the remaining ingredients.
  5. Bake to Perfection: Place the casserole in the preheated oven and bake for 25-30 minutes. You’ll know it’s done when the biscuits are cooked through and golden brown, and the cheese is melted and bubbly.
A top-down view of the finished biscuit pizza casserole, garnished with fresh basil in a rustic baking dish.
Baked to golden, bubbly perfection and ready in under an hour!

Pro-Tips for Casserole Success

Want to ensure your Biscuit Pizza Casserole is absolutely perfect? Follow these simple tips from a seasoned home cook.

  • Drain the Grease Thoroughly: To prevent a soggy bottom, make sure you drain all the excess fat from the cooked ground beef before adding the sauce.
  • Don’t Use Compressed Biscuits: For the best results, use the larger, layered or flaky style refrigerated biscuits. They puff up beautifully and create a wonderful texture.
  • Shred Your Own Cheese: Pre-shredded cheese is often coated with anti-caking agents that prevent it from melting as smoothly. Grating a block of mozzarella yourself makes a world of difference.

Fun Variations and Topping Ideas

One of the best things about this ground beef pizza casserole is how easy it is to customize. Treat it like a pizza and get creative with your favorite toppings!

Topping Swaps

  • Supreme Pizza: Add cooked Italian sausage, sliced bell peppers, onions, and black olives.
  • Veggie Lovers: Skip the meat and load it up with sautéed mushrooms, onions, bell peppers, and spinach.
  • Meat Lovers: Combine the ground beef with cooked Italian sausage, bacon bits, and extra pepperoni.
A scoop of ground beef pizza casserole on a spatula, being lifted from a baking dish, showing the cheesy layers.
Layers of cheese, sauce, and biscuits make every bite irresistible.

Storing, Freezing, and Reheating Leftovers

This casserole is just as good the next day! To store, let it cool completely, then cover the baking dish tightly with foil or a lid and refrigerate for up to 3 days. To reheat, you can warm individual portions in the microwave or cover the entire dish with foil and bake at 350°F (175°C) until heated through.

For a longer storage option, you can also freeze it. Assemble the casserole but don’t bake it. Cover it tightly with both plastic wrap and foil and freeze for up to 3 months. Thaw overnight in the refrigerator before baking as directed.

Frequently Asked Questions

Yes! You can assemble the entire casserole, cover it tightly, and refrigerate it for up to 24 hours before baking. You may need to add a few minutes to the baking time since it will be starting from cold.

The key is to drain the grease from the cooked ground beef as thoroughly as possible. Any excess fat can make the bottom layer of biscuits soggy during baking.

Store leftovers in an airtight container in the refrigerator for up to 3 days. You can reheat individual portions in the microwave or cover the baking dish with foil and bake at 350°F (175°C) until warmed through.

Large, flaky-style refrigerated biscuits (like Pillsbury Grands!) work best. They create a fluffy, tender crust that holds up well to the sauce and toppings.

Almost any of your favorite pizza toppings will work! Try adding cooked Italian sausage, sautéed mushrooms, bell peppers, onions, or black olives. Just be sure to pre-cook any raw vegetables or meats before adding them.

More Hearty Casseroles to Try

If you love the ease and comfort of a good casserole, you’re in the right place. Be sure to check out our incredibly popular Million Dollar Spaghetti Casserole for another pasta-based favorite. And for a dish that’s pure comfort, don’t miss this Cheesy Beef and Potato Casserole. Looking for another family friendly dinner? Try these Cowboy Butter Chicken Bites!

Get the Full Biscuit Pizza Casserole Recipe!

A scoop of ground beef pizza casserole on a spatula, being lifted from a baking dish, showing the cheesy layers.

Biscuit Pizza Casserole: The Ultimate Easy Weeknight Dinner

This Biscuit Pizza Casserole is a cheesy, savory, and incredibly easy weeknight meal. Made with refrigerated biscuits, ground beef, and your favorite pizza toppings, it's a family-friendly dinner that's ready in under an hour!
Prep Time 15 minutes
Cook Time 25 minutes
Total Time 40 minutes
Servings: 8 servings
Course: Dinner, Main Course
Cuisine: American, Italian-American
Calories: 450

Ingredients
  

  • 1 lb lean ground beef or ground turkey
  • 1 jar (15 oz) pizza sauce
  • 1 can (16.3 oz) refrigerated biscuits such as Pillsbury Grands!
  • 1 cup sliced pepperoni
  • 2 cups shredded mozzarella cheese
  • 1 tsp Italian seasoning
  • 1/2 tsp garlic powder
  • 1/2 tsp onion powder

Equipment

  • 1 9x13 inch Baking Dish
  • 1 Large Skillet

Instructions
 

  1. Preheat oven to 375°F (190°C). Lightly grease a 9x13 inch baking dish.
  2. In a large skillet, cook the ground beef over medium-high heat until browned. Drain any excess grease. Stir in the pizza sauce, Italian seasoning, garlic powder, and onion powder. Bring to a simmer.
  3. Open the can of biscuits and cut each biscuit into quarters.
  4. Arrange half of the biscuit pieces in the bottom of the prepared dish. Top with half of the meat sauce, half of the pepperoni, and half of the mozzarella cheese. Repeat the layers with the remaining ingredients.
  5. Bake for 25-30 minutes, or until the biscuits are cooked through and the casserole is golden and bubbly. Let stand for 5 minutes before serving.

Notes

Tip 1: For extra flavor, add a sprinkle of grated Parmesan cheese over the top before baking.
Tip 2: Ensure the ground beef is well-drained to prevent the casserole from becoming greasy.
Tip 3: Feel free to add other pizza toppings like cooked sausage, mushrooms, or bell peppers between the layers.

Share Your Casserole Creation!

We are so excited for you to try this Biscuit Pizza Casserole recipe! It’s a dish that brings smiles to the dinner table every time. If you make it, please leave a comment below and let us know what you think. And don’t forget to save this recipe to your favorite board on Pinterest!

A close-up shot of a golden-brown biscuit pizza casserole in a baking dish, showcasing the melted cheese, pepperoni, and fluffy biscuit top.
The whole family will love this easy Biscuit Pizza Casserole!

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