Get ready to transform your weeknight dinner routine with this unbelievably delicious Biscuit Pizza Casserole. Imagine all the cheesy, savory flavors of your favorite pizza combined with the fluffy, golden goodness of buttery biscuits, all baked together in one simple dish. It’s a guaranteed crowd-pleaser that brings the whole family running to the table. This recipe isn’t just easy; it’s a game-changer for busy evenings when you crave comfort food without the fuss.
Why You’ll Love This Biscuit Pizza Casserole Recipe
This isn’t just another casserole; it’s a one-dish wonder that simplifies your life and satisfies everyone’s cravings. Here’s why it will become a staple in your meal plan.
- Incredibly Easy: Using refrigerated biscuit dough and simple pantry staples, this dish comes together in minutes. It’s the perfect recipe for beginner cooks or hectic weeknights.
- Completely Customizable: Just like a regular pizza, you can load this casserole with all your favorite toppings. From pepperoni and sausage to bell peppers and olives, the possibilities are endless.
- Family-Approved: It’s a fun and delicious mashup of two beloved classics. Kids love the biscuit base, and adults appreciate the hearty, satisfying flavors.
- Perfect for Any Occasion: Whether it’s a quick family dinner, a potluck, or a game day feast, this casserole is always a hit.
The Simple Ingredients You’ll Need
The magic of this recipe lies in its simplicity. You only need a handful of common ingredients to create this cheesy masterpiece.
- Refrigerated Biscuits: One can of large refrigerated biscuits serves as the fluffy, tender crust.
- Ground Beef: One pound of lean ground beef creates a hearty, savory base. You can also substitute ground turkey or sausage.
- Pizza Sauce: Your favorite jar of pizza sauce brings that classic, tangy pizza flavor.
- Mozzarella Cheese: Freshly shredded mozzarella cheese melts into a glorious, gooey layer of perfection.
- Pepperoni: Sliced pepperoni adds a touch of classic spice and flavor.
- Italian Seasoning: A sprinkle of this blend of dried herbs enhances the pizza aroma and taste.
- Onion & Garlic: These aromatics build a deep, savory flavor foundation for the meat sauce.
Step-by-Step Instructions: How to Make Biscuit Pizza Casserole
Follow these simple steps to create a perfect casserole. We’ll walk you through each stage, from prepping the ingredients to baking it until bubbly and golden.
Step 1: Prep Your Oven and Pan
First things first, preheat your oven to 375°F (190°C). Grease a 9×13-inch baking dish with non-stick spray or butter. Open the can of biscuits and cut each one into quarters. Set them aside for later.
Step 2: Cook the Meat and Aromatics
In a large skillet over medium-high heat, cook the ground beef with the diced onion until the beef is browned and the onion is soft. Drain off any excess grease. Add the minced garlic and cook for another minute until fragrant.

Step 3: Create the Pizza Filling
Stir the pizza sauce and Italian seasoning into the ground beef mixture. Season with salt and pepper to your taste. Let it simmer for a few minutes to allow the flavors to meld together beautifully.
Step 4: Assemble the Casserole
Now for the fun part! Arrange the quartered biscuit pieces in the bottom of your prepared baking dish. Pour the meat sauce evenly over the biscuits. Sprinkle a generous layer of shredded mozzarella cheese over the top, then arrange the pepperoni slices.
Step 5: Bake to Golden Perfection
Place the casserole in the preheated oven and bake for 25-30 minutes. You’ll know it’s done when the biscuits are cooked through and puffed up, and the cheese is melted, bubbly, and slightly browned. Let it cool for a few minutes before serving to allow it to set.
Tips for the Best-Ever Biscuit Casserole
Want to guarantee a perfect result every time? Follow these expert tips for a truly unforgettable Biscuit Pizza Casserole.
- Don’t Crowd the Biscuits: Make sure the biscuit pieces are in a single layer to ensure they cook through and puff up properly.
- Shred Your Own Cheese: For the best melt, buy a block of mozzarella and shred it yourself. Pre-shredded cheeses often contain anti-caking agents that can prevent them from melting smoothly.
- Avoid a Soggy Bottom: If you’re using extra saucy toppings, you can pre-bake the biscuit pieces for about 10 minutes before adding the toppings. This helps create a firmer crust.
- Let it Rest: Allowing the casserole to sit for 5-10 minutes after baking helps it set, making it much easier to slice and serve.
Fun & Delicious Variations to Try
One of the best things about this recipe is how easy it is to customize. Here are a few ideas to get you started on your own biscuit pizza bake creations.
Meat Lover’s Delight
Load it up by adding cooked sausage, bacon crumbles, and diced ham to the ground beef mixture for an extra hearty meal.
Supreme Pizza Casserole
For a supreme version, add sautéed bell peppers, onions, mushrooms, and black olives along with the pepperoni and sausage.

Vegetarian Dream
Skip the meat entirely and load your casserole with a mix of roasted vegetables like zucchini, bell peppers, mushrooms, and onions. A sprinkle of feta or parmesan can add an extra flavor boost.
White Pizza Casserole
Swap the red pizza sauce for a creamy Alfredo sauce or a garlic and olive oil base. Add cooked chicken, spinach, and ricotta cheese for a delicious twist on a white pizza.
What to Serve with Your Casserole
This Biscuit Pizza Casserole is a hearty meal on its own, but it pairs wonderfully with a few simple sides. A crisp green salad with a light vinaigrette is a refreshing contrast to the cheesy richness. For a more complete meal, consider serving it with some delicious Honey Roasted Carrots or a side of perfectly crispy Air Fryer Broccoli. If you’re feeling extra cozy, a slice of Fluffy Honey Cornbread is perfect for soaking up any extra sauce.
Storage, Reheating, and Make-Ahead Instructions
Have leftovers or want to prep ahead? No problem! This casserole is just as delicious the next day.
Storing Leftovers
Store any leftover casserole tightly covered in the refrigerator for up to 3 days. The flavors will continue to meld, making it even tastier.
How to Reheat
You can reheat individual portions in the microwave for a quick meal. For best results and to keep the biscuits from getting soggy, reheat the casserole in a 350°F (175°C) oven until warmed through.
Can I Make This Ahead?
Yes! You can assemble the entire casserole, cover it tightly, and refrigerate it for up to 24 hours before baking. You may need to add a few extra minutes to the baking time since it will be cold from the fridge.
Frequently Asked Questions (FAQs)
Yes, this is a great make-ahead meal. You can assemble the entire casserole, cover it, and store it in the refrigerator for up to 24 hours. Just add 5-10 minutes to the baking time since it will be starting from cold.
Absolutely! Homemade biscuit dough works wonderfully. Just be sure to pre-bake it for about 10-12 minutes before adding the toppings to ensure the bottom cooks through properly.
The best way to avoid a soggy bottom is to not use too much sauce. You can also lightly pre-bake the biscuit pieces for about 10 minutes before you add the sauce and other toppings. This creates a firmer base.
Store leftovers in an airtight container in the refrigerator for up to 3 days. For best results, reheat in an oven at 350°F (175°C) until warmed through, which helps keep the biscuits from getting soft.
The options are endless! Try adding cooked Italian sausage, sautéed mushrooms, black olives, bell peppers, or even pineapple and ham for a Hawaiian twist. You can customize it just like a regular pizza.
The Ultimate Biscuit Pizza Casserole Recipe

Biscuit Pizza Casserole: The Ultimate Cheesy & Easy Family Dinner
Ingredients
Equipment
Instructions
- Preheat oven to 375°F (190°C). Grease a 9x13-inch baking dish. Cut each biscuit into four pieces.
- In a large skillet, cook the ground beef and diced onion over medium-high heat until the beef is browned. Drain excess grease. Add minced garlic and cook for 1 more minute.
- Stir in the pizza sauce and Italian seasoning. Season with salt and pepper. Simmer for 2-3 minutes.
- Place the quartered biscuit pieces in the bottom of the prepared dish. Pour the meat sauce mixture over the biscuits. Top with shredded mozzarella cheese and pepperoni slices.
- Bake for 25-30 minutes, or until the biscuits are cooked through and the cheese is melted and bubbly.
- Let the casserole rest for 5-10 minutes before serving. This helps it set and makes for easier slicing.
Notes
Feel free to add any of your favorite pizza toppings like mushrooms, olives, or bell peppers to the meat mixture.
Share Your Creation!
We hope you love this Biscuit Pizza Casserole as much as we do! It’s the kind of simple, satisfying meal that makes dinner a joy. If you try it, be sure to leave a comment below and let us know your favorite toppings. Don’t forget to share a photo of your masterpiece on Pinterest!
